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Previous work demonstrated an accelerated in vitro and in vivo wound healing response when insulinoma cells were used to deliver insulin to scratches in keratinocyte mono- layers and chronic diabetic excise wounds in mice, respectively. When combined with mesenchymal stem cells (MSCs), the response was amplified (healing in 14 vs. 35+ days). To isolate the role of insulin in the response and exclude any potential contribution of an unknown cancer moiety released by the insulinoma cells, the effect on wound healing of multiple lines derived from the same insulinoma was examined.more » « less
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Iturbide, E; Aubdoollah, Z; Soni, S; Olabisi, R (, Northeast Bioengineering Conference)Previous work demonstrated an accelerated in vitro and in vivo wound healing response when insulinoma cells were used to deliver insulin to scratches in keratinocyte mono- layers and chronic diabetic excise wounds in mice, respectively. When combined with mesenchymal stem cells (MSCs), the response was amplified (healing in 14 vs. 35+ days). To isolate the role of insulin in the response and exclude any potential contribution of an un known cancer moiety released by the insulinoma cells, the effect on wound healing of multiple lines derived from the same insulinoma was examined.more » « less
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